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Seeing the Unseen

The QISI System

Acquire and Analyze Live, Motile Sperm Cells as if they were Stained

 
 

The Technology

Underlying the QISI (Quantitative Interferometric Sperm Imager) system is a new and revolutionary imaging methodology intended for acquiring, measuring and quantitatively analyzing individually selected sperm cells for injection into the oocyte.

The Unmet Need

Lack of visual and quantitative information contributing to poor success rates.

QISI should increase the number of high-quality cells for injection, by providing accurate information on cell structure, including accurate measurements and a clear indication for the cell compliance with WHO2010 consensus criteria

The Solution

How can this Help my Fertility Practice?

With QISI you can provide your clients with cutting-edge IVF/ICSI service by making an informed decision regarding sperm cells selected for injection.

How Does It Work?

QISI uses a coherent light source, in a uniquely configured interferometer, which measures light delay as it passes different locations across the sperm cell.

 

The amount of delay provides a non-invasive method to generate differential contrast between various compartments of the sperm cell, like chemical (structural) staining.

 

This additional real time information allows for morphometric assessments to be conducted and compared with the World Health Organization WHO-2010 sperm assessment criteria.

 

“Virtual DFI**” technology is a revolutionary feature for estimating DNA fragmentation in live cells. (currently for investigational use only).

 

The QISI system is based on long term research and numerous peer-reviewed publications in the Tel-Aviv University (Israel), by professor N. Shaked, QART’s co-founder. See “Publications” on page 6.

** DFI: DNA Fragmentation Index

QISI Virtually Stained

QISI System Components

The system comprises a low intensity coherent light source in the visible red band and a compact, state-of-the-art interferometer unit, incorporating a high-quality Olympus inverted microscope backbone.

 

QISI is fitted with a top-of-the-line Narishige micro-manipulator unit for sperm handling and selection and high-performance PC with display and peripherals, for image analysis, measurements display and data logging.

QISI System Specifications

System configuration:
• Standard inverted microscope add-on. Base microscope: Olympus CKX53*
• Coherent light & brightfield (BF) simultaneous imaging

Imaging illumination:
• Bright field: adjustable LED white light (max 4W)
• Coherent light: HeNe laser, 633nm, 0.8mW, 0.48mm beam diameter.

Cameras:
• 6MP Color camera (BF)
• 6MP Monochrome camera (holographic)

Magnification:
• x20 for setup only
• x60 for imaging

Field of view:

Eyepiece:
22mm (round)
0.36mm on sample plane with x60 lens
1.1mm on sample plane with x20 lens

Brightfield Camera:
7.41 x 4.98mm imager, with x0.35 adapter: 21.17 x 14.22mm
0.35 x 0.24mm on sample plane with x60 lens
1.05 x 0.71mm on sample plane with x20 lens

Holographic camera:
7.41 x 4.98mm imager, with x0.972 adapter: 7.62 x 5.12mm
0.132 x 0.085mm on sample plane with x60 lens
Note: x20 lens is not used for holographic imaging.

Sperm manipulation:
• Narishige** Three-axis Joystick, Hydraulic
• Narishige Pneumatic Microinjector

Image analysis:
• System PC, Intel Processor.

Data backup, logging & retrieval:
• Report (electronic or printed) includes sperm image with detected segments and measurements.
• Optional electronic backup (video) of selection process
• Optional voice remarks.

Display:
• 24” / 27” (option) wide FHD display (16:9, 1920x1080)

Control:
• Standard keyboard & mouse
• Dual foot pedal (Left: Start/Stop imaging, Right assignable: Audio remark recording)

Safety:
• Complies with IEC/EN 601010-1 (Electrical Safety)
• Complies with IEC/EN 61326 (Electro-Magnetic Compatibility)
• Complies with IEC/EN 60825-1 (Laser)
• MEA / Mouse ICSI safety tests

*OLYMPUS is a trademark of OLYMPUS CORPORATION
** NARISHIGE is a trademark of Narishige scientific instrument

 
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